Issue 27, 2013
From the journal:

Journal of Materials Chemistry B

Osteogenic potential of a biosilica-coated P(UDMA-co-MPS) copolymer†

Matthias Wiens,*a   Thomas Niem,b   Tarek A. Elkhooly,a   Renate Steffen,a   Sebastian Neumann,a   Ute Schloßmachera  and  Werner E. G. Müllera  

* Corresponding authors

a Institute of Physiological Chemistry, University Medical Center, Johannes Gutenberg-University, Duesbergweg 6, D-55128 Mainz, Germany
E-mail: wiens@uni-mainz.de
Tel: +49 6131 39 25961

b Gesellschaft für Dentale Forschung und Innovationen, Dieselstrasse 5-6, D-61191 Rosbach, Germany

Abstract

A P(UDMA-co-MPS) copolymer was surface-functionalized through the polycondensation activity of the enzyme silicatein. The resulting biosilica coating significantly enhanced mineralization of osteoblastic cells, thereby revealing its osteogenic potential. Consequently, the functionalized copolymer may be explored as an alternative to conventionally used acrylics in applications where stable bone–material interfaces are required.

Graphical abstract: Osteogenic potential of a biosilica-coated P(UDMA-co-MPS) copolymer

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Article information

DOI
https://doi.org/10.1039/C3TB20325E
Article type
Communication
Submitted
08 Mar 2013
Accepted
23 May 2013
First published
24 May 2013

J. Mater. Chem. B, 2013,1, 3339-3343

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Osteogenic potential of a biosilica-coated P(UDMA-co-MPS) copolymer

M. Wiens, T. Niem, T. A. Elkhooly, R. Steffen, S. Neumann, U. Schloßmacher and W. E. G. Müller, J. Mater. Chem. B, 2013, 1, 3339 DOI: 10.1039/C3TB20325E

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