Issue 22, 2014

Polymer sieving matrices in microanalytical electrophoresis

Abstract

Microfluidic design has advanced existing protein separation capabilities and supported novel assays. Key metrics for successful protein separations include fast, robust, and sensitive analysis of complex mixtures of bio-macromolecules. Attaining high separation resolution is a chief concern. Here we review recent advances in polymer-based electrophoresis sieving materials that are impacting microfluidic bioanalytical applications. Looking forward, we comment on unmet needs for advanced separation media in micro-to-nanoscale devices.

Graphical abstract: Polymer sieving matrices in microanalytical electrophoresis

Article information

Article type
Critical Review
Submitted
01 Jul 2014
Accepted
07 Aug 2014
First published
08 Aug 2014

Analyst, 2014,139, 5635-5654

Polymer sieving matrices in microanalytical electrophoresis

M. Chung, D. Kim and A. E. Herr, Analyst, 2014, 139, 5635 DOI: 10.1039/C4AN01179A

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