Efficient and accelerated growth of multifunctional dendrimers using orthogonal thiol–ene and SN2 reactions

Abstract

An orthogonal coupling strategy was developed by combining thiol–ene and S_N2 reactions, which was subsequently applied to the accelerated synthesis of multifunctional dendrimers using carbohydrate building blocks. In surface plasmon resonance (SPR) studies, the β-D-galactopyranoside-coated dendrimer exhibited nM binding affinity with the bacterial LecA lectin extracted from Pseudomonas aeruginosa.