Here we report a spectroscopic, electrochemical and computational study of cytochrome c showing that nitration of Tyr74 induces Tyr deprotonation, which is coupled to Met/Lys axial ligand exchange, and results in concomitant gain of peroxidatic activity at physiological pH.
D. A. Capdevila, D. Álvarez-Paggi, M. A. Castro, V. Tórtora, V. Demicheli, D. A. Estrín, R. Radi and D. H. Murgida, Chem. Commun., 2014, 50, 2592 DOI: 10.1039/C3CC47207H
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