A range of N-acylpyrrolo[3,4-c]isoxazoles and derived N-acyltetramides has been prepared via a nitrile oxide dipolar cycloaddition approach, as analogues of the acyltetramic acid metabolite reutericyclin, of interest for its antibiotic potential against Gram-positive bacteria including hospital-acquired infections of resistant Clostridium difficile.
R. C. F. Jones, J. P. Bullous, C. C. M. Law and M. R. J. Elsegood, Chem. Commun., 2014, 50, 1588 DOI: 10.1039/C3CC47867J
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