Issue 14, 2014
From the journal:

Chemical Communications

Palladium-catalyzed double C–H activation: one-pot synthesis of benzo[c]pyrazolo[1,2-a]cinnolin-1-ones from 5-pyrazolones and aryl iodides†

Zhoulong Fan,a   Kui Wu,b   Li Xing,c   Qizheng Yaob  and  Ao Zhang*a  

* Corresponding authors

a CAS Key Laboratory of Receptor Research, and Synthetic Organic & Medicinal Chemistry Laboratory (SOMCL), Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China
E-mail: aozhang@simm.ac.cn

b Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China

c Nano Science and Technology Institute, University of Science and Technology of China, Suzhou 215123, China

Abstract

A palladium-catalyzed dual C–H activation to construct C–C/C–N bonds for one-pot synthesis of benzo[c]pyrazolo[1,2-a]cinnolin-1-ones is successfully developed. This approach involves using a pyrazolone moiety as an internal directing group for C–H activation, and provides a flexible strategy to access this polycyclic skeleton.

Graphical abstract: Palladium-catalyzed double C–H activation: one-pot synthesis of benzo[c]pyrazolo[1,2-a]cinnolin-1-ones from 5-pyrazolones and aryl iodides

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Article information

DOI
https://doi.org/10.1039/C3CC47989G
Article type
Communication
Submitted
17 Oct 2013
Accepted
05 Dec 2013
First published
06 Dec 2013

Chem. Commun., 2014,50, 1682-1684

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Palladium-catalyzed double C–H activation: one-pot synthesis of benzo[c]pyrazolo[1,2-a]cinnolin-1-ones from 5-pyrazolones and aryl iodides

Z. Fan, K. Wu, L. Xing, Q. Yao and A. Zhang, Chem. Commun., 2014, 50, 1682 DOI: 10.1039/C3CC47989G

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