Issue 14, 2014
From the journal:

Chemical Communications

Enzyme-triggered gelation: targeting proteases with internal cleavage sites†

Steven C. Bremmer,ab   Anne J. McNeil*a  and  Matthew B. Soellner*b  

* Corresponding authors

a Department of Chemistry and Macromolecular Science and Engineering Program, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan, USA
E-mail: ajmcneil@umich.edu

b Departments of Chemistry and Medicinal Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan, USA
E-mail: soellner@med.umich.edu

Abstract

A generalizable method for detecting protease activity via gelation is described. A recognition sequence is used to target the protease of interest while a second protease is used to remove the residual residues from the gelator scaffold. Using this approach, selective assays for both MMP-9 and PSA are demonstrated.

Graphical abstract: Enzyme-triggered gelation: targeting proteases with internal cleavage sites

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Article information

DOI
https://doi.org/10.1039/C3CC48132H
Article type
Communication
Submitted
23 Oct 2013
Accepted
18 Dec 2013
First published
19 Dec 2013

Chem. Commun., 2014,50, 1691-1693

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Enzyme-triggered gelation: targeting proteases with internal cleavage sites

S. C. Bremmer, A. J. McNeil and M. B. Soellner, Chem. Commun., 2014, 50, 1691 DOI: 10.1039/C3CC48132H

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