Enantioselective 1,4-additions of ClMeAl(CH![[double bond, length as m-dash]](https://www.rsc.org/images/entities/char_e001.gif)
CHR) (R = alkyl, alkenyl, Ph) to cyclohexenones†
Abstract
Chloromethylvinyl alanes (E)-ClMeAl(CHCHR) prepared directly from terminal alkynes undergo 1,4-addition to cyclohexenone and 3-methylcyclohexenone in moderate to good yield (30–70%) and good to excellent stereoselectivity (80–98% ee) using readily available copper(I) sources and chiral ligands.
![Graphical abstract: Enantioselective 1,4-additions of ClMeAl(CH [[double bond, length as m-dash]] CHR) (R = alkyl, alkenyl, Ph) to cyclohexenones](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C3CC48191C&imageInfo.ImageIdentifier.Year=2014)
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![[double bond, length as m-dash]](https://www.rsc.org/images/entities/h2_char_e001.gif)
CHR) (R = alkyl, alkenyl, Ph) to cyclohexenones
