Issue 28, 2014
From the journal:

Chemical Communications

Salt as a catalyst in the mitochondria: returning cytochrome c to its native state after it misfolds on the surface of cardiolipin containing membranes†

Leah A. Pandisciaa  and  Reinhard Schweitzer-Stenner*a  

* Corresponding authors

a Department of Chemistry, Drexel University, 3141 Chestnut Street, Philadelphia, PA, USA
E-mail: rschweitzer-stenner@drexel.edu

Abstract

Cytochrome c binding to cardiolipin receptors on the surface of TOCL/DOPC(20% : 80%) liposomes induces a conformational change, which is not reversible after the protein's dissociation at low ionic strength. Addition of 100 mM NaCl switches the protein back to its native state.

Graphical abstract: Salt as a catalyst in the mitochondria: returning cytochrome c to its native state after it misfolds on the surface of cardiolipin containing membranes

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Article information

DOI
https://doi.org/10.1039/C3CC48709A
Article type
Communication
Submitted
14 Nov 2013
Accepted
05 Dec 2013
First published
05 Dec 2013

Chem. Commun., 2014,50, 3674-3676

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Salt as a catalyst in the mitochondria: returning cytochrome c to its native state after it misfolds on the surface of cardiolipin containing membranes

L. A. Pandiscia and R. Schweitzer-Stenner, Chem. Commun., 2014, 50, 3674 DOI: 10.1039/C3CC48709A

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