Discrimination of lymph node metastases using desorption electrospray ionisation-mass spectrometry imaging

N. Abbassi-Ghadi; K. Veselkov; S. Kumar; J. Huang; E. Jones; N. Strittmatter; H. Kudo; R. Goldin; Z. Takáts; G. B. Hanna

doi:10.1039/C3CC48927B

Discrimination of lymph node metastases using desorption electrospray ionisation-mass spectrometry imaging†

N. Abbassi-Ghadi,‡^a K. Veselkov,‡^a S. Kumar,^a J. Huang,^a E. Jones,^a N. Strittmatter,^a H. Kudo,^b R. Goldin,^b Z. Takáts §*^a and G. B. Hanna §*^a

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^a Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM Wing, St Mary's Hospital, London, UK
E-mail: g.hanna@imperial.ac.uk, z.takats@imperial.ac.uk

^b Centre for Pathology, Imperial College London, 4th Floor Clarence Wing, St Mary's Hospital, London, UK

Abstract

Desorption electrospray ionisation mass spectrometry imaging (DESI-MSI) has been used for the identification of cancer within lymph nodes with accurate spatial distribution in comparison to gold standard matched immuno-histopathological images. The metabolic profile of the cancerous lymph nodes was similar to that of the primary tumour site.

Chemical Communications

Discrimination of lymph node metastases using desorption electrospray ionisation-mass spectrometry imaging†

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Discrimination of lymph node metastases using desorption electrospray ionisation-mass spectrometry imaging

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