Issue 32, 2014

A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(ii) probe for in vivo imaging of live neurons

Abstract

Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, {[Pt(L1)]2(μ-dppm)}2+ (1) and {[Pt(L2)]2(μ-dppm)}2+ (2), as lysosome-specific two-photon imaging probes.

Graphical abstract: A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(ii) probe for in vivo imaging of live neurons

Supplementary files

Additions and corrections

Article information

Article type
Communication
Submitted
22 Nov 2013
Accepted
24 Dec 2013
First published
03 Jan 2014

Chem. Commun., 2014,50, 4161-4163

A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons

Y. Ho, N. B. Au, K. Wong, C. T. Chan, W. Kwok, G. Law, K. Tang, W. Wong, C. E. Ma and M. H. Lam, Chem. Commun., 2014, 50, 4161 DOI: 10.1039/C3CC48934E

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