Issue 23, 2014
From the journal:

Chemical Communications

Self-assembled hybrid nanoparticles for targeted co-delivery of two drugs into cancer cells†

Fujian Huang,ab   Mingxu You,ac   Tao Chen,ac   Guizhi Zhu,ac   Haojun Liang*b  and  Weihong Tan*ac  

* Corresponding authors

a Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center and Center for Research at the Interface of Bio/Nano, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, USA
E-mail: tan@chem.ufl.edu

b CAS Key Laboratory of Soft Matter Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China
E-mail: hjliang@ustc.edu.cn
Fax: +86-551-63607824
Tel: +86-551-63607824

c Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Hunan University, Changsha, China

Abstract

A therapeutic aptamer–lipid–poly(lactide-co-glycolic acid) hybrid nanoparticle-based drug delivery system was prepared and characterized. This system can co-deliver two different drugs with distinct solubility and different anticancer mechanisms to target cancer cells with high specificity and efficiency.

Graphical abstract: Self-assembled hybrid nanoparticles for targeted co-delivery of two drugs into cancer cells

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Article information

DOI
https://doi.org/10.1039/C3CC49003C
Article type
Communication
Submitted
25 Nov 2013
Accepted
27 Jan 2014
First published
28 Jan 2014

Chem. Commun., 2014,50, 3103-3105

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Self-assembled hybrid nanoparticles for targeted co-delivery of two drugs into cancer cells

F. Huang, M. You, T. Chen, G. Zhu, H. Liang and W. Tan, Chem. Commun., 2014, 50, 3103 DOI: 10.1039/C3CC49003C

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