Thirteen novel non-canonical amino acids were synthesized and tested for suppression of an amber codon using a mutant pyrrolysyl-tRNA synthetase–tRNAPylCUA pair. Suppression was observed with varied efficiencies. One non-canonical amino acid in particular contains an azide that can be applied for site-selective protein labeling.
A. Tuley, Y. Wang, X. Fang, Y. Kurra, Y. H. Rezenom and W. R. Liu, Chem. Commun., 2014, 50, 2673 DOI: 10.1039/C3CC49068H
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