Issue 38, 2014
From the journal:

Chemical Communications

A novel example of double 6-exo-trig heterocyclization: nitrile conversion to new anticancer active (HeLa cells) primary amine ionic liquids†

Denis Prodius,*ab   Hamid Saeed Shah,c   Jamshed Iqbal,c   Anastasia Macaeva,b   Anatoli Dimoglo,d   George E. Kostakis,a   Nicolas Zill,a   Fliur Macaevb  and  Annie K. Powell*ae  

* Corresponding authors

a Institute of Nanotechnology, Karlsruhe Institute of Technology, Hermann-von-Helmholtz Platz 1, 76344 Eggenstein-Leopoldshafen, Germany
E-mail: annie.powell@kit.edu
Fax: +49 721-608-48142
Tel: +49 721-608-42135

b Institute of Chemistry of the Academy of Sciences of Moldova, Academiei str. 3, MD-2028 Chisinau, Moldova
E-mail: denis.prodius@kit.edu

c Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan

d Gebze Institute of Technology, Department of Environmental Engineering, 41400 Cayirova, Kocaeli, Turkey

e Institute of Inorganic Chemistry, Karlsruhe Institute of Technology, Engesserstrasse 15, 76128 Karlsruhe, Germany

Abstract

Conversion of nitriles under mild conditions leads to a new class of primary amines, including room temperature ionic liquids, acting as efficient anticancer agents.

Graphical abstract: A novel example of double 6-exo-trig heterocyclization: nitrile conversion to new anticancer active (HeLa cells) primary amine ionic liquids

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3CC49759C
Article type
Communication
Submitted
24 Dec 2013
Accepted
29 Jan 2014
First published
29 Jan 2014

Chem. Commun., 2014,50, 4888-4890

Author version available

Download author version (PDF)

Permissions

Request permissions

A novel example of double 6-exo-trig heterocyclization: nitrile conversion to new anticancer active (HeLa cells) primary amine ionic liquids

D. Prodius, H. S. Shah, J. Iqbal, A. Macaeva, A. Dimoglo, G. E. Kostakis, N. Zill, F. Macaev and A. K. Powell, Chem. Commun., 2014, 50, 4888 DOI: 10.1039/C3CC49759C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements