Issue 23, 2014
From the journal:

Chemical Communications

Syntheses of lactosyl ceramide analogues carrying novel bifunctional BODIPY dyes directed towards the differential analysis of multiplexed glycosphingolipids by MS/MS using iTRAQ†

Sang-Hyun Son,a   Shusaku Daikoku,a   Atsuko Ohtake,a   Katsuhiko Suzuki,a   Kazuya Kabayama,b   Yukishige Itoac  and  Osamu Kanie*abc  

* Corresponding authors

a Japan Science and Technology Agency (JST), ERATO, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan

b Institute of Physical and Chemical Research (RIKEN), Synthetic Cellular Chemistry Laboratory, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan

c Tokai University, Institute of Glycoscience, 4-1-1 Kitakaname, Hiratsuka-shi, Kanagawa 259-1292, Japan
E-mail: kanie@tokai-u.jp

Abstract

Lactosyl ceramide analogues carrying novel bifunctional BODIPY-based fluorescent tags were designed and synthesised for live cell imaging. Addition of azide functionality on the fluorophore facilitated isobaric tagging for quantitative multiplexed analysis of biomolecules based on tandem mass spectrometry.

Graphical abstract: Syntheses of lactosyl ceramide analogues carrying novel bifunctional BODIPY dyes directed towards the differential analysis of multiplexed glycosphingolipids by MS/MS using iTRAQ

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Article information

DOI
https://doi.org/10.1039/C4CC00112E
Article type
Communication
Submitted
07 Jan 2014
Accepted
29 Jan 2014
First published
31 Jan 2014

Chem. Commun., 2014,50, 3010-3013

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Syntheses of lactosyl ceramide analogues carrying novel bifunctional BODIPY dyes directed towards the differential analysis of multiplexed glycosphingolipids by MS/MS using iTRAQ

S. Son, S. Daikoku, A. Ohtake, K. Suzuki, K. Kabayama, Y. Ito and O. Kanie, Chem. Commun., 2014, 50, 3010 DOI: 10.1039/C4CC00112E

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