Issue 57, 2014
From the journal:

Chemical Communications

Self-assembled nanoparticles as multifunctional drugs for anti-microbial therapies†

Manpreet Bhatti,*a   Timothy D. McHugh,b   Lilia Milanesic  and  Salvador Tomas*a  

* Corresponding authors

a Institute of Structural and Molecular Biology and Department of Biological Sciences, School of Science, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK
E-mail: s.tomas@bbk.ac.uk, m.bhatti@ucl.ac.uk

b Centre for Clinical Microbiology, Royal Free Campus, University College London, Rowland Hill Street, London NW3 2QG, UK

c School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK

Abstract

A self-assembled nanoparticle containing a photosensitizer and a Trojan-horse moiety (cholesterol), binds an anti-TB pro-drug and increases 1000-fold its activity against mycobacteria. These minimalist constructs will allow development of economically viable, efficient drug preparations for the treatment of drug-resistant TB infections.

Graphical abstract: Self-assembled nanoparticles as multifunctional drugs for anti-microbial therapies

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Article information

DOI
https://doi.org/10.1039/C4CC00349G
Article type
Communication
Submitted
15 Jan 2014
Accepted
22 May 2014
First published
22 May 2014

Chem. Commun., 2014,50, 7649-7651

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Self-assembled nanoparticles as multifunctional drugs for anti-microbial therapies

M. Bhatti, T. D. McHugh, L. Milanesi and S. Tomas, Chem. Commun., 2014, 50, 7649 DOI: 10.1039/C4CC00349G

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