Issue 51, 2014
From the journal:

Chemical Communications

MnII-containing coordination nanoparticles as highly efficient T1 contrast agents for magnetic resonance imaging†

Gabriella Paul,a   Yoann Prado,a   Nada Dia,ab   Eric Rivière,a   Sophie Laurent,c   Mathieu Roch,d   Luce Vander Elst,cd   Robert N. Muller,cd   Lucie Sancey,e   Pascal Perriat,f   Olivier Tillement,e   Talal Mallaha  and  Laure Catala*a  

* Corresponding authors

a Institut de Chimie Moléculaire et des Matériaux d'Orsay, CNRS, Université Paris 11, 91405 Orsay, France
E-mail: laure.catala@u-psud.fr
Fax: +33169154754
Tel: +33169157890

b Ecole Doctorale des Sciences et de Technologie, Hadath campus P.O. Box 5, Université Libanaise Beyrouth, Lebanon

c Univ Mons, NMR & Mol Imaging Lab, Dept Gen Organ & Biomed Chem, B-7000 Mons, Belgium

d CMMI: Center for Microscopy and Molecular Imaging, Rue Adrienne Bolland, 8, B-6041 Gosselies, Belgium

e Institut Lumière Matière Equipe FENNEC - UMR CNRS 5306 - Univ. Lyon 1Bâtiment Jules Raulin, 2, rue V. Grignard, 69622 Villeurbanne, France

f INSA Lyon, 7, Avenue Jean Capelle, 69621 Villeurbanne, France

Abstract

Large longitudinal relaxivities were observed in MnII-containing Prussian blue analogue nanoparticles. At low concentrations and high field (7 T), a remarkable positive contrast enhancement was seen which exceeded that of clinical contrast agents and was attributed to the very large proportion of surface atoms of these coordination nanoparticles.

Graphical abstract: MnII-containing coordination nanoparticles as highly efficient T1 contrast agents for magnetic resonance imaging

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Article information

DOI
https://doi.org/10.1039/C4CC01251H
Article type
Communication
Submitted
17 Feb 2014
Accepted
28 Apr 2014
First published
01 May 2014

Chem. Commun., 2014,50, 6740-6743

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MnII-containing coordination nanoparticles as highly efficient T1 contrast agents for magnetic resonance imaging

G. Paul, Y. Prado, N. Dia, E. Rivière, S. Laurent, M. Roch, L. V. Elst, R. N. Muller, L. Sancey, P. Perriat, O. Tillement, T. Mallah and L. Catala, Chem. Commun., 2014, 50, 6740 DOI: 10.1039/C4CC01251H

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