Issue 46, 2014
From the journal:

Chemical Communications

An enantioselective cascade reaction between α,β-unsaturated aldehydes and malonic half-thioesters: a rapid access to chiral δ-lactones†

Qiao Ren,ab   Shaofa Sun,*a   Jiayao Huang,b   Wenjun Li,b   Minghu Wu,a   Haibing Guoa  and  Jian Wang*ab  

* Corresponding authors

a Hubei Collaborative Innovation Centre for Non-power Nuclear Technology, College of Chemistry and Biological Sciences, Hubei University of Science and Technology, Hubei Province 437100, People's Republic China

b Department of Chemistry, National University of Singapore, Block S15, Level 5, 3 Science Drive 3, Singapore 117543, Singapore
E-mail: chmwangj@nus.edu.sg
Fax: +65-6779-1691

Abstract

We disclose a novel efficient enantioselective organocatalytic cascade reaction for the preparation of δ-lactones in good to excellent yields (69–93%) and with high to excellent enantioselectivities (88–96% ee).

Graphical abstract: An enantioselective cascade reaction between α,β-unsaturated aldehydes and malonic half-thioesters: a rapid access to chiral δ-lactones

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Article information

DOI
https://doi.org/10.1039/C4CC01736F
Article type
Communication
Submitted
07 Mar 2014
Accepted
15 Apr 2014
First published
15 Apr 2014

Chem. Commun., 2014,50, 6137-6140

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An enantioselective cascade reaction between α,β-unsaturated aldehydes and malonic half-thioesters: a rapid access to chiral δ-lactones

Q. Ren, S. Sun, J. Huang, W. Li, M. Wu, H. Guo and J. Wang, Chem. Commun., 2014, 50, 6137 DOI: 10.1039/C4CC01736F

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