Issue 41, 2014
From the journal:

Chemical Communications

Biosynthesis of the antibiotic tropodithietic acid by the marine bacterium Phaeobacter inhibens†

Nelson L. Brock,a   Alexander Nikolaya  and  Jeroen S. Dickschat*a  

* Corresponding authors

a Institut für Organische Chemie, Hagenring 30, 38106 Braunschweig, Germany
E-mail: j.dickschat@tu-braunschweig.de
Fax: +49 531 3915272
Tel: +49 531 3915264

Abstract

The biosynthesis of tropodithietic acid was investigated using a combinatorial approach of feeding experiments, gene knockouts and bioinformatic analyses. The mechanism of sulfur introduction is distinct from known mechanisms in holomycin, thiomarinol A and gliotoxin biosynthesis.

Graphical abstract: Biosynthesis of the antibiotic tropodithietic acid by the marine bacterium Phaeobacter inhibens

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Article information

DOI
https://doi.org/10.1039/C4CC01924E
Article type
Communication
Submitted
14 Mar 2014
Accepted
03 Apr 2014
First published
10 Apr 2014

Chem. Commun., 2014,50, 5487-5489

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Biosynthesis of the antibiotic tropodithietic acid by the marine bacterium Phaeobacter inhibens

N. L. Brock, A. Nikolay and J. S. Dickschat, Chem. Commun., 2014, 50, 5487 DOI: 10.1039/C4CC01924E

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