Hydrotrifluoromethylthiolation of α-diazo esters – synthesis of α-SCF3 substituted esters

Quentin Lefebvre; Eleonora Fava; Pavlo Nikolaienko; Magnus Rueping

doi:10.1039/C4CC02060J

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Hydrotrifluoromethylthiolation of α-diazo esters – synthesis of α-SCF₃ substituted esters†

Quentin Lefebvre,^a Eleonora Fava,^a Pavlo Nikolaienko^a and Magnus Rueping*^a

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* Corresponding authors

^a Institute of Organic Chemistry, RWTH Aachen, Landoltweg1, 52074 Aachen, Germany
E-mail: Magnus.Rueping@rwth-aachen.de
Fax: +49-241-8092665
Tel: +49-241-80 94686

Abstract

A practical protocol for hydrotrifluoromethylthiolation of diazo compounds has been developed. A range of diazo compounds in combination with a nucleophilic SCF₃ source provided access to valuable trifluoromethylthiolated compounds. Furthermore, a methodology for the first double trifluoromethylthiolation was developed.

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Article information

DOI: https://doi.org/10.1039/C4CC02060J
Article type: Communication
Submitted: 19 Mar 2014
Accepted: 01 May 2014
First published: 13 May 2014

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Chem. Commun., 2014,50, 6617-6619

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Hydrotrifluoromethylthiolation of α-diazo esters – synthesis of α-SCF₃ substituted esters

Q. Lefebvre, E. Fava, P. Nikolaienko and M. Rueping, Chem. Commun., 2014, 50, 6617 DOI: 10.1039/C4CC02060J

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