Issue 53, 2014
From the journal:

Chemical Communications

A size amplified immune magnetic microbeads strategy in the rapid detection of circulating tumor cells†

Hongyan Zhang,‡ab   Yanhong Wang,‡b   Qingling Li,a   Fumiao Zhangb  and  Bo Tang*a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan, China
E-mail: tangb@sdnu.edu.cn
Fax: +86 531 86180017
Tel: +86 531 86180010

b College of Life Science, Shandong Normal University, Jinan, China
E-mail: shwzhhy@163.com
Tel: +86 531 86182691

Abstract

Using anti-EpCAM antibody modified magnetic microbeads allowed us to simultaneously apply size-amplification and magnetic labelling of CTCs to the capture and purification of CTCs by membrane filtration and immune-magnetic separation. High purity capture (>98%), rapid (<2 hours) and simple detection of CTCs were realized.

Graphical abstract: A size amplified immune magnetic microbeads strategy in the rapid detection of circulating tumor cells

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Article information

DOI
https://doi.org/10.1039/C4CC02342K
Article type
Communication
Submitted
29 Mar 2014
Accepted
06 May 2014
First published
07 May 2014

Chem. Commun., 2014,50, 7024-7027

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A size amplified immune magnetic microbeads strategy in the rapid detection of circulating tumor cells

H. Zhang, Y. Wang, Q. Li, F. Zhang and B. Tang, Chem. Commun., 2014, 50, 7024 DOI: 10.1039/C4CC02342K

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