Issue 57, 2014
From the journal:

Chemical Communications

Copper-mediated pyrazole synthesis from 2,3-allenoates or 2-alkynoates, amines and nitriles†

Bo Chen,‡a   Can Zhu,‡a   Yang Tanga  and  Shengming Ma*ab  

* Corresponding authors

a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, P. R. China

b Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, P. R. China
E-mail: masm@sioc.ac.cn
Fax: +86-21-6260-9305

Abstract

An efficient copper-mediated three-component reaction of 2,3-allenoates or 2-alkynoates, amines, and nitriles affording fully substituted pyrazoles with a very nice diversity has been developed. A tandem conjugate addition, 1,2-addition, and N–N bond formation mechanism has been proposed for this diverse synthesis of pyrazoles based on mechanistic studies.

Graphical abstract: Copper-mediated pyrazole synthesis from 2,3-allenoates or 2-alkynoates, amines and nitriles

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Article information

DOI
https://doi.org/10.1039/C4CC02856B
Article type
Communication
Submitted
24 Apr 2014
Accepted
21 May 2014
First published
22 May 2014

Chem. Commun., 2014,50, 7677-7679

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Copper-mediated pyrazole synthesis from 2,3-allenoates or 2-alkynoates, amines and nitriles

B. Chen, C. Zhu, Y. Tang and S. Ma, Chem. Commun., 2014, 50, 7677 DOI: 10.1039/C4CC02856B

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