Issue 56, 2014
From the journal:

Chemical Communications

Highly effective copper-mediated gem-difluoromethylenation of arylboronic acids†

Guobin Ma,a   Wen Wan,*a   Qingyang Hu,a   Haizhen Jiang,a   Jing Wang,a   Shizheng Zhub  and  Jian Hao*ab  

* Corresponding authors

a School of Materials Science and Engineering, Department of Chemistry, Shanghai University, Shanghai 200444, China
E-mail: wanwen@staff.shu.edu.cn, jhao@shu.edu.cn

b Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China

Abstract

A copper-mediated gem-difluoromethylenation of aryl, heteroaryl and vinyl boronic acids with bromodifluoromethylated oxazole or thiazole derivatives has been developed. This novel reaction showed an excellent functional group tolerance and wide substrate scope, providing facile access to practical application in drug discovery and development.

Graphical abstract: Highly effective copper-mediated gem-difluoromethylenation of arylboronic acids

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Article information

DOI
https://doi.org/10.1039/C4CC03321C
Article type
Communication
Submitted
04 May 2014
Accepted
20 May 2014
First published
03 Jun 2014

Chem. Commun., 2014,50, 7527-7530

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Highly effective copper-mediated gem-difluoromethylenation of arylboronic acids

G. Ma, W. Wan, Q. Hu, H. Jiang, J. Wang, S. Zhu and J. Hao, Chem. Commun., 2014, 50, 7527 DOI: 10.1039/C4CC03321C

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