Zinc-catalyzed synthesis of 2-alkenylfurans via cross-coupling of enynones and diazo compounds†
Abstract
Inexpensive, less-toxic ZnCl2 serves as the catalyst for selective cross-coupling of enynones and diazo compounds, an unprecedented reaction pathway for zinc carbenoids. A cascade sequence comprising formal cyclization/cross-coupling leads to a variety of 2-alkenylfurans.