The first enantioselective vinylogous aldol–cyclization cascade reaction of allyl pyrazoleamides with isatins is reported. With 1 mol% of Takemoto catalyst, optically active spirocyclic oxindole–dihydropyranones were obtained in excellent yields (93–99%) and good-to-excellent enantioselectivities (82–97% ee).
T. Li, Y. Jiang, Y. Guan, F. Sha and X. Wu, Chem. Commun., 2014, 50, 10790 DOI: 10.1039/C4CC04235B
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