A novel cancer targeting and pH-responsive prodrug was successfully designed and synthesized. This M-prodrug was demonstrated to have real-time drug release monitoring capability based on the concept of contact-mediated quenching between doxorubicin and a coumarin derivative.
S. Li, L. Liu, H. Jia, W. Qiu, L. Rong, H. Cheng and X. Zhang, Chem. Commun., 2014, 50, 11852 DOI: 10.1039/C4CC05008H
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