Issue 87, 2014
From the journal:

Chemical Communications

Design of novel chiral N,N,O-tridentate phenanthroline ligands and their application to enantioselective addition of organozinc reagents to aldehydes†

Yuki Naganawa,*a   Tomoya Namba,a   Tomotaka Aoyama,a   Kentaro Shojia  and  Hisao Nishiyama*a  

* Corresponding authors

a Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, Japan
E-mail: yuki.n@apchem.nagoya-u.ac.jp, hnishi@apchem.nagoya-u.ac.jp

Abstract

The novel N,N,O-tridentate phenanthroline ligand (BinThro) bearing an axially chiral binaphthyl backbone prepared from BINOL was found to be an effective chiral catalyst for enantioselective addition of diethylzinc to aromatic aldehydes with high enantioselectivity (up to 95% ee).

Graphical abstract: Design of novel chiral N,N,O-tridentate phenanthroline ligands and their application to enantioselective addition of organozinc reagents to aldehydes

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Article information

DOI
https://doi.org/10.1039/C4CC05020G
Article type
Communication
Submitted
01 Jul 2014
Accepted
24 Jul 2014
First published
25 Jul 2014

Chem. Commun., 2014,50, 13224-13227

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Design of novel chiral N,N,O-tridentate phenanthroline ligands and their application to enantioselective addition of organozinc reagents to aldehydes

Y. Naganawa, T. Namba, T. Aoyama, K. Shoji and H. Nishiyama, Chem. Commun., 2014, 50, 13224 DOI: 10.1039/C4CC05020G

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