A novel method for the synthesis of the polysubstituted tetrahydro-4H-pyrido[1,2-a]pyrimidines through a domino desulfurative coupling–acylation–hydration and Michael addition sequence was established.
![Graphical abstract: A domino desulfurative coupling–acylation–hydration–Michael addition process for the synthesis of polysubstituted tetrahydro-4H-pyrido[1,2-a]pyrimidines](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C4CC05090H&imageInfo.ImageIdentifier.Year=2014)
Z. Yan, Z. Quan, Y. Da, Z. Zhang and X. Wang, Chem. Commun., 2014, 50, 13555 DOI: 10.1039/C4CC05090H
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