Issue 88, 2014
From the journal:

Chemical Communications

Highly efficient and selective phosphorylation of amino acid derivatives and polyols catalysed by 2-aryl-4-(dimethylamino)pyridine-N-oxides – towards kinase-like reactivity†

James I. Murray,a   Rudiger Woscholskiab  and  Alan C. Spivey*a  

* Corresponding authors

a Department of Chemistry, South Kensington Campus, Imperial College London, SW7 2AZ, UK
E-mail: a.c.spivey@imperial.ac.uk

b Institute of Chemical Biology, Imperial College London, London SW7 2AZ, UK

Abstract

The chemoselective phosphorylation of hydroxyl containing amino acid derivatives and polyols by phosphoryl chlorides catalyzed by 2-aryl-4-(dimethylamino)pyridine-N-oxides is described.

Graphical abstract: Highly efficient and selective phosphorylation of amino acid derivatives and polyols catalysed by 2-aryl-4-(dimethylamino)pyridine-N-oxides – towards kinase-like reactivity

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Article information

DOI
https://doi.org/10.1039/C4CC05388E
Article type
Communication
Submitted
12 Jul 2014
Accepted
16 Sep 2014
First published
16 Sep 2014

Chem. Commun., 2014,50, 13608-13611

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Highly efficient and selective phosphorylation of amino acid derivatives and polyols catalysed by 2-aryl-4-(dimethylamino)pyridine-N-oxides – towards kinase-like reactivity

J. I. Murray, R. Woscholski and A. C. Spivey, Chem. Commun., 2014, 50, 13608 DOI: 10.1039/C4CC05388E

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