Issue 87, 2014
From the journal:

Chemical Communications

Sensitive and selective amplified visual detection of cytokines based on exonuclease III-aided target recycling†

Kai Zhang,‡*a   Tianli Ren,‡b   Ke Wang,a   Xue Zhu,a   Hao Wua  and  Minhao Xie*a  

* Corresponding authors

a Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine. Wuxi, Jiangsu 214063, China
E-mail: zhangkai@jsinm.org, xieminhao@jsinm.org
Fax: +86-510-85520770
Tel: +86-510-85514482

b Department of Immunology and Rheumatology, The Second People's Hospital of Wuxi, Wuxi, Jiangsu 214000, China

Abstract

A new Exo III assisted strand-cleavage cycle and ligand-responsive quadruplex formation strategy for amplified and label-free detection of IFN-γ was reported with a detection limit of 0.1 pM and a visual detection limit of 20 pM by the naked eye.

Graphical abstract: Sensitive and selective amplified visual detection of cytokines based on exonuclease III-aided target recycling

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Article information

DOI
https://doi.org/10.1039/C4CC05701E
Article type
Communication
Submitted
23 Jul 2014
Accepted
10 Sep 2014
First published
10 Sep 2014

Chem. Commun., 2014,50, 13342-13345

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Sensitive and selective amplified visual detection of cytokines based on exonuclease III-aided target recycling

K. Zhang, T. Ren, K. Wang, X. Zhu, H. Wu and M. Xie, Chem. Commun., 2014, 50, 13342 DOI: 10.1039/C4CC05701E

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