Issue 86, 2014
From the journal:

Chemical Communications

Monovalent maleimide functionalization of gold nanoparticles via copper-free click chemistry†

D. J. Nieves,a   N. S. Azmi,ab   R. Xu,ac   R. Lévy,a   E. A. Yatesa  and  D. G. Fernig*a  

* Corresponding authors

a Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool, UK L69 7ZB
E-mail: dgfernig@liv.ac.uk

b Faculty of Industrial Sciences and Technology, Universiti Malaysia Pahang, Kuantan, Malaysia

c Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary, University of London, London

Abstract

A single maleimide was installed onto the self-assembled monolayer of gold nanoparticles by copper-free click chemistry. Simple covalent biofunctionalisation is demonstrated by coupling fibroblast growth factor 2 and an oligosaccharide in a 1 : 1 stoichiometry by thiol-Michael addition.

Graphical abstract: Monovalent maleimide functionalization of gold nanoparticles via copper-free click chemistry

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Article information

DOI
https://doi.org/10.1039/C4CC05909C
Article type
Communication
Submitted
29 Jul 2014
Accepted
09 Sep 2014
First published
09 Sep 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 13157-13160

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Monovalent maleimide functionalization of gold nanoparticles via copper-free click chemistry

D. J. Nieves, N. S. Azmi, R. Xu, R. Lévy, E. A. Yates and D. G. Fernig, Chem. Commun., 2014, 50, 13157 DOI: 10.1039/C4CC05909C

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