Issue 90, 2014
From the journal:

Chemical Communications

Electrochemically driven drug metabolism via a CYP1A2–UGT1A10 bienzyme confined in a graphene nano-cage†

Jusheng Lu,a   Yuanjian Zhang,a   Henan Li,a   Jiachao Yua  and  Songqin Liu*a  

* Corresponding authors

a Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China
E-mail: liusq@seu.edu.cn

Abstract

A graphene nano-cage with regulatable space for the assembly of a cytochrome P450 1A2–UDP-glucuronosyltransferase 1A10 bienzyme complex has been constructed via a click reaction, and successfully used to study drug sequential metabolism using an electrochemically-driven method.

Graphical abstract: Electrochemically driven drug metabolism via a CYP1A2–UGT1A10 bienzyme confined in a graphene nano-cage

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Article information

DOI
https://doi.org/10.1039/C4CC06200K
Article type
Communication
Submitted
08 Aug 2014
Accepted
08 Sep 2014
First published
08 Sep 2014

Chem. Commun., 2014,50, 13896-13899

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Electrochemically driven drug metabolism via a CYP1A2–UGT1A10 bienzyme confined in a graphene nano-cage

J. Lu, Y. Zhang, H. Li, J. Yu and S. Liu, Chem. Commun., 2014, 50, 13896 DOI: 10.1039/C4CC06200K

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