A convenient metal-free method for the synthesis of 3-aryl isoindolinones via TfOH catalyzed aromatic C–H functionalization of electron-rich arenes with 2-formylbenzonitriles is developed. This process provided a new efficient strategy for the synthesis of isoindolinone derivatives in good to high yields and regioselectivities by forming two bonds.
J. Hu, H. Qin, W. Xu, J. Li, F. Zhang and H. Zheng, Chem. Commun., 2014, 50, 15780 DOI: 10.1039/C4CC06653G
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