Issue 26, 2014
From the journal:

Dalton Transactions

Aqueous chemistry and antiproliferative activity of a pyrone-based phosphoramidate Ru(arene) anticancer agent†

Samuel M. Meier,ab   Maria S. Novak,a   Wolfgang Kandioller,ab   Michael A. Jakupec,ab   Alexander Roller,a   Bernhard K. Kepplerab  and  Christian G. Hartinger*abc  

* Corresponding authors

a University of Vienna, Institute of Inorganic Chemistry, Waehringer Str. 42, A-1090 Vienna, Austria

b University of Vienna, Research Platform “Translational Cancer Therapy Research”, Waehringer Str. 42, A-1090 Vienna, Austria

c University of Auckland, School of Chemical Sciences, Private Bag 92019, Auckland 1142, New Zealand
E-mail: c.hartinger@auckland.ac.nz
Tel: +64 9 373 7955, ext. 83220

Abstract

A water-stable phosphoramidate Ru(arene) metallodrug shows antiproliferative activity comparable to KP1019 in human cancer cell lines. This novel compound can cross-link the peptide backbone of cytochrome c, but features low apoptosis inducing properties.

Graphical abstract: Aqueous chemistry and antiproliferative activity of a pyrone-based phosphoramidate Ru(arene) anticancer agent

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Article information

DOI
https://doi.org/10.1039/C4DT00569D
Article type
Communication
Submitted
24 Feb 2014
Accepted
02 May 2014
First published
06 May 2014

Dalton Trans., 2014,43, 9851-9855

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Aqueous chemistry and antiproliferative activity of a pyrone-based phosphoramidate Ru(arene) anticancer agent

S. M. Meier, M. S. Novak, W. Kandioller, M. A. Jakupec, A. Roller, B. K. Keppler and C. G. Hartinger, Dalton Trans., 2014, 43, 9851 DOI: 10.1039/C4DT00569D

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