Mononuclear complexes of amide-based ligands containing appended functional groups: role of secondary coordination spheres on catalysis

Abstract

Amide-based ligands H₂L¹, H₂L² and H₂L³ containing thiazole, thiazoline and benzothiazole appended groups have been used to synthesize Zn²⁺ (1 and 3), Cd²⁺ complexes (2 and 4), and a Mn²⁺ complex (5). In all cases, potentially multidentate ligands create a meridional N₃ coordination environment around the M(II) ion whereas additional sites are occupied by labile nitrate ions in 1–4 and MeOH in 5. Interestingly, metal complexation caused the migration of protons from amidic N–H sites to the appended heterocyclic rings in complexes 1–4. Structural studies show that the protonated heterocyclic rings in these complexes create a hydrogen bond based cavity adjacent to the metal ion. Importantly, binding studies confirm that the substrates are bound within the complex cavity closer to the Lewis acidic metal in all complexes including the oxidation-sensitive Mn ion in complex 5. All complexes have been utilized as the reusable and heterogeneous catalysts for ring-opening reactions of assorted epoxides, cyanation reactions of various aldehydes, and epoxidation reactions of several olefins.