Issue 3, 2014
From the journal:

Green Chemistry

A facile protocol for the synthesis of 3-aminoimidazo-fused heterocycles via the Groebke–Blackburn–Bienayme reaction under catalyst-free and solvent-free conditions†

Shinde Vidyacharan,a   Anand H. Shinde,a   Bishnupada Satpathia  and  Duddu S. Sharada*a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology, Ordinance Factory Estate, Yeddumailaram-502205, Medak District, Hyderabad, Andhra Pradesh, India
E-mail: sharada@iith.ac.in

Abstract

A one-pot catalyst, solvent, work-up and column free synthesis of 3-aminoimidazo-fused heterocycles by a three-component reaction of a 2-aminoheterocycle, aldehyde, and isocyanide is presented. This efficient and green protocol has the advantages of environmental friendliness, high yields and operational simplicity.

Graphical abstract: A facile protocol for the synthesis of 3-aminoimidazo-fused heterocycles via the Groebke–Blackburn–Bienayme reaction under catalyst-free and solvent-free conditions

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Article information

DOI
https://doi.org/10.1039/C3GC42130A
Article type
Communication
Submitted
14 Oct 2013
Accepted
05 Dec 2013
First published
05 Dec 2013

Green Chem., 2014,16, 1168-1175

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A facile protocol for the synthesis of 3-aminoimidazo-fused heterocycles via the Groebke–Blackburn–Bienayme reaction under catalyst-free and solvent-free conditions

S. Vidyacharan, A. H. Shinde, B. Satpathi and D. S. Sharada, Green Chem., 2014, 16, 1168 DOI: 10.1039/C3GC42130A

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