Issue 3, 2014

Catalyst- and solvent-free, pot, atom and step economic synthesis of tetrahydroquinazolines by an aza-Diels–Alder reaction strategy

Abstract

A pot, atom and step economic (PASE) synthesis of tetrahydroquinazolines has been achieved via a microwave-assisted four-component catalyst- and solvent-free aza-Diels–Alder reaction strategy. The key step of the methodology is the in situ generation of both the diene and the dienophile and their subsequent reaction to give the desired product.

Graphical abstract: Catalyst- and solvent-free, pot, atom and step economic synthesis of tetrahydroquinazolines by an aza-Diels–Alder reaction strategy

Supplementary files

Article information

Article type
Communication
Submitted
21 Nov 2013
Accepted
23 Dec 2013
First published
02 Jan 2014

Green Chem., 2014,16, 1158-1162

Author version available

Catalyst- and solvent-free, pot, atom and step economic synthesis of tetrahydroquinazolines by an aza-Diels–Alder reaction strategy

D. Bhuyan, R. Sarma, Y. Dommaraju and D. Prajapati, Green Chem., 2014, 16, 1158 DOI: 10.1039/C3GC42389A

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