C(sp3)–C(sp3) bond formation via copper/Brønsted acid co-catalyzed C(sp3)–H bond oxidative cross-dehydrogenative-coupling (CDC) of azaarenes

Fang-Fang Wang; Cui-Ping Luo; Guojun Deng; Luo Yang

doi:10.1039/C4GC00038B

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C(sp³)–C(sp³) bond formation via copper/Brønsted acid co-catalyzed C(sp³)–H bond oxidative cross-dehydrogenative-coupling (CDC) of azaarenes†

Fang-Fang Wang,^a Cui-Ping Luo,^a Guojun Deng^a and Luo Yang*^a

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* Corresponding authors

^a Key Laboratory for Environmentally Friendly Chemistry and Application of the Ministry of Education, Department of Chemistry, Xiangtan University, Hunan, China
E-mail: yangluo@xtu.edu.cn
Fax: +86-731-58292251
Tel: +86-731-58298351

Abstract

A copper/Brønsted acid dual-catalyst promoted oxidative cross-dehydrogenative-coupling of alkylazaarenes and tertiary amines for C(sp³)–C(sp³) bond formation was developed. This method uses dioxygen as the terminal oxidant under mild reaction conditions and would provide a convenient benzylic C–H transformation of alkylazaarenes to biologically active pharmaceutics.

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Article information

DOI: https://doi.org/10.1039/C4GC00038B
Article type: Communication
Submitted: 09 Jan 2014
Accepted: 29 Jan 2014
First published: 31 Jan 2014

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Green Chem., 2014,16, 2428-2431

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C(sp³)–C(sp³) bond formation via copper/Brønsted acid co-catalyzed C(sp³)–H bond oxidative cross-dehydrogenative-coupling (CDC) of azaarenes

F. Wang, C. Luo, G. Deng and L. Yang, Green Chem., 2014, 16, 2428 DOI: 10.1039/C4GC00038B

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