We developed a computational model to predict oxygen levels in microfluidic plastic devices during cell culture. This model is based on experimental evaluation of oxygen levels. Conditions are determined that provide adequate oxygen supply to two cell types, hepatocytes and endothelial cells, either by diffusion through the plastic device, or by supplying a low flow rate of medium.
C. J. Ochs, J. Kasuya, A. Pavesi and R. D. Kamm, Lab Chip, 2014, 14, 459 DOI: 10.1039/C3LC51160J
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