Cell models based on human nasal epithelial stem/progenitor cells (hNESPCs) are developed to obtain functional ciliated cells on modified Transwell inserts. The live hNECs are integrated into microfluidic platforms to mimic the 3D features of the human upper airway for in vitro testing of gaseous formaldehyde toxicity via airway delivery.
W. Wang, Y. Yan, C. W. Li, H. M. Xia, S. S. Chao, D. Y. Wang and Z. P. Wang, Lab Chip, 2014, 14, 677 DOI: 10.1039/C3LC51208H
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