Issue 11, 2014
From the journal:

Nanoscale

LL37 peptide@silver nanoparticles: combining the best of the two worlds for skin infection control†

Mariana Vignoni,‡a   Hasitha de Alwis Weerasekera,a   Madeline J. Simpson,a   Jaywant Phopase,b   Thien-Fah Mah,c   May Griffith,*b   Emilio I. Alarcon*a  and  Juan C. Scaiano*ab  

* Corresponding authors

a Department of Chemistry and Centre for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario, Canada
E-mail: emilio@photo.chem.uottawa.ca, scaiano@photo.chem.uottawa.ca

b Integrative Regenerative Medicine Centre, Departments of Clinical and Experimental Medicine and Physics, Chemistry and Biology, Linköping University, S-58185 Linköping, Sweden
E-mail: may.griffith@liu.se

c Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada

Abstract

Capping silver nanoparticles with LL37 peptide eradicates the antiproliferative effect of silver on primary skin cells, but retains the bactericidal properties of silver nanoparticles with activities comparable to silver nitrate or silver sulfadiazine. In addition, LL37 capped silver nanoparticles have anti-biofilm formation activity.

Graphical abstract: LL37 peptide@silver nanoparticles: combining the best of the two worlds for skin infection control

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Article information

DOI
https://doi.org/10.1039/C4NR01284D
Article type
Communication
Submitted
08 Mar 2014
Accepted
19 Apr 2014
First published
22 Apr 2014

Nanoscale, 2014,6, 5725-5728

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LL37 peptide@silver nanoparticles: combining the best of the two worlds for skin infection control

M. Vignoni, H. de Alwis Weerasekera, M. J. Simpson, J. Phopase, T. Mah, M. Griffith, E. I. Alarcon and J. C. Scaiano, Nanoscale, 2014, 6, 5725 DOI: 10.1039/C4NR01284D

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