Issue 22, 2014
From the journal:

Organic & Biomolecular Chemistry

Rh(iii)-catalyzed regioselective hydroarylation of alkynes via directed C–H functionalization of pyridines†

Zhen-Chao Qian,a   Jun Zhou,a   Bo Li,a   Fang Hua  and  Bing-Feng Shi*a  

* Corresponding authors

a Department of Chemistry, Zhejiang Univers ity, Hangzhou 310027, China
E-mail: bfshi@zju.edu.cn

Abstract

Rh(III)-catalyzed C-3 selective alkenylation of pyridine derivatives via hydroarylation of alkynes has been developed. The reaction shows high regioselectivity, high yield and good functional group tolerance, providing a convenient strategy for the synthesis of trisubstituted (pyridin-3-yl)alkenes.

Graphical abstract: Rh(iii)-catalyzed regioselective hydroarylation of alkynes via directed C–H functionalization of pyridines

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Article information

DOI
https://doi.org/10.1039/C4OB00612G
Article type
Communication
Submitted
22 Mar 2014
Accepted
09 Apr 2014
First published
10 Apr 2014

Org. Biomol. Chem., 2014,12, 3594-3597

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Rh(III)-catalyzed regioselective hydroarylation of alkynes via directed C–H functionalization of pyridines

Z. Qian, J. Zhou, B. Li, F. Hu and B. Shi, Org. Biomol. Chem., 2014, 12, 3594 DOI: 10.1039/C4OB00612G

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