Issue 5, 2014
From the journal:

Polymer Chemistry

Anticancer camptothecin-N-poly(lactic acid) nanoconjugates with facile hydrolysable linker†

Qian Yin,a   Rong Tong,‡a   Lichen Yin,a   Timothy M. Fanb  and  Jianjun Cheng*a  

* Corresponding authors

a Department of Materials Science and Engineering, University of Illinois at Urbana – Champaign, Urbana, IL 61801, USA
E-mail: jianjunc@illinois.edu

b Department of Veterinary Clinical Medicine, University of Illinois at Urbana – Champaign, Urbana, Illinois 61801, USA

Abstract

We report a strategy of conjugating CPT to the terminal carboxylate group of polylactide (PLA) with a facile hydrolysable amino ester linker via a controlled polymerization method. The obtained CPT-N-PLA conjugates were able to self-assemble into 50–100 nanometer-sized conjugates (NCs) with desired in vitro physicochemical properties and showed enhanced in vivo therapeutic efficacy against Lewis lung carcinoma (LLC) induced in C57BL/6 mice.

Graphical abstract: Anticancer camptothecin-N-poly(lactic acid) nanoconjugates with facile hydrolysable linker

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Article information

DOI
https://doi.org/10.1039/C3PY01245J
Article type
Communication
Submitted
06 Sep 2013
Accepted
27 Sep 2013
First published
03 Oct 2013

Polym. Chem., 2014,5, 1581-1585

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Anticancer camptothecin-N-poly(lactic acid) nanoconjugates with facile hydrolysable linker

Q. Yin, R. Tong, L. Yin, T. M. Fan and J. Cheng, Polym. Chem., 2014, 5, 1581 DOI: 10.1039/C3PY01245J

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