Formation of glutathione sulfenate and sulfinate complexes by an organoiridium(iii) anticancer complex†
Abstract
The organoiridium(III) anticancer complex [(η5-Cpxbiph)Ir(phpy)py] (Cpxbiph = biphenyltetramethylcyclopentadienyl, phpy = phenylpyridine, py = pyridine) unexpectedly reacts with the tripeptide glutathione in the presence of coenzyme NADH to give glutathione sulfenate (Ir–S(O)G) and sulfinate (Ir–S(O)2G) complexes. These new adducts may play a role in the anticancer activity of such organoiridium complexes.