Issue 2, 2014
From the journal:

Organic Chemistry Frontiers

Fusarisetins: structure–function studies on a novel class of cell migration inhibitors†

Eduardo J. E. Caro-Diaz,a   Aereas Aung,b   Jing Xu,a   Shyni Vargheseb  and  Emmanuel A. Theodorakis*a  

* Corresponding authors

a Department of Chemistry & Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
E-mail: etheodor@ucsd.edu

b Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA

Abstract

Herein, we report the effects of fusarisetin A on cell morphology focusing in particular on actin and microtubules dynamics. We also report the synthesis and structure–function studies of a designed library of synthetic fusarisetins in cell-based assays.

Graphical abstract: Fusarisetins: structure–function studies on a novel class of cell migration inhibitors

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Article information

DOI
https://doi.org/10.1039/C3QO00067B
Article type
Research Article
Submitted
13 Dec 2013
Accepted
29 Jan 2014
First published
07 Feb 2014

Org. Chem. Front., 2014,1, 135-139

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Fusarisetins: structure–function studies on a novel class of cell migration inhibitors

E. J. E. Caro-Diaz, A. Aung, J. Xu, S. Varghese and E. A. Theodorakis, Org. Chem. Front., 2014, 1, 135 DOI: 10.1039/C3QO00067B

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