Synthesis and application of a new triphosphorus ligand for regioselective linear hydroformylation: a potential way for the stepwise replacement of PPh3 for industrial use

Abstract

A new triphosphorus ligand, Tribi, was developed for the regioselective linear hydroformylation of terminal and internal olefins. It was shown to have excellent catalytic activity and regioselectivity. More importantly, the synthesis of the new triphosphorus ligand was scaled-up (>140 g scale) for practical industrial use. An effective method was also developed for the stepwise replacement of PPh₃ by Tribi for potential industrial use.