The flow regime was implemented as a non-chemical alternative for the reaction control and detrimental acid byproduct sequestration in transition metal catalyzed cross-coupling reactions. The concept was illustrated on the Sonogashira reaction and resulted in a non-basic version of the cross-coupling protocols.
S. Voltrova and J. Srogl, Org. Chem. Front., 2014, 1, 1067 DOI: 10.1039/C4QO00198B
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