1,2-Alkylarylation of activated alkenes with dual C–H bonds of arenes and alkyl halides toward polyhalo-substituted oxindoles

Abstract

We describe here a new visible light facilitated radical strategy for 1,2-alkylarylation of activated alkenes with a C(sp²)–H bond of arenes and a C(sp³)–H bond of alkyl halides. This method achieves selective scission of the C(sp³)–H bond adjacent to halide atoms leading to a halo-substituted alkyl radical, and provides a new synthetic utilization of aryl halides toward polyhalo-substituted oxindoles in good to excellent yields. Moreover, the concise transformation of the products, polyhalo-substituted oxindoles, into vinyl halides and alkynyl halides was also illustrated.