Novel light-responsive nanoparticles based on an amphiphile with a single photolabile linker between its hydrophilic head and hydrophobic tail was developed for small interfering RNA (siRNA) delivery. Upon UV exposure, cleavage of the linkage resulted in rapid shell detachment of the nanoparticles, which facilitated siRNA release and enhanced gene silencing efficiency.
H. Li, H. Wang, C. Sun, J. Du and J. Wang, RSC Adv., 2014, 4, 1961 DOI: 10.1039/C3RA44866E
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