Synthesis of fused tetrahydropyrido[2,3-c]coumarin derivatives as potential inhibitors for dopamine d3 receptors, catalyzed by hydrated ferric sulfate

Abstract

Fused furo- and pyrano-tetrahydropyrido[2,3-c]coumarin derivatives were synthesized using one-pot three component reactions between aromatic aldehydes, 3-aminocoumarins and cyclic enol ethers in the presence of 10 mol% hydrated ferric sulphate [Fe₂(SO₄)₃·xH₂O] in refluxing acetonitrile. The salient features of the present protocol are good yields, high diastereoselectivities, application to a wide range of substrates, using an inexpensive, readily available and recyclable catalyst and environmentally benign reaction conditions.